Undergraduate Institution: Veterinary College Bidar, India

PhD Institution: Oakland University, Michigan

Research Description

My research goal is to study pathogenesis of highly pathogenic coronaviruses in a mouse model. I am particularly interested in unraveling the role of innate immune cells in mediating host protection vs immunopathology.

Publication(s)

Channappanavar R, L Lu, S Xia, L Du, DK Meyerholz, S Perlman, S Jiang (2015) Protective effect of intranasal regimens containing peptidic MERS-CoV fusion inhibitor against MERS-CoV infection. Journal of Infectious Diseases, jiv325.

Zhang N, Channappanavar R, Ma C, Wang L, Tang J, Garron T, Tao X, Tasneem S, Lu L, Tseng CT, Zhou Y, Perlman S, Jiang S, Du L (2015) Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus. Cell Mol Immunol. 2015 Feb 2. doi: 10.1038/cmi.2015.03

Fehr AR, Athmer J, Channappanavar R, Phillips JM, Meyerholz DK, Perlman S. (2015) The nsp3 macrodomain promotes virulence in mice with coronavirus-induced encephalitis. J Virol. 89(3):1523-36.

Trujillo JA, Croft NP, Dudek NL, Channappanavar R, Theodossis A, Webb AI, Dunstone MA, Illing PT, Butler NS, Fett C, Tscharke DC, Rossjohn J, Perlman S, Purcell AW (2014) The cellular redox environment alters antigen presentation. J Biol Chem. 289(40):27979-91.

Channappanavar R, Fett C, Zhao J, Meyerholz DK, Perlman S. (2014) Virus-specific memory CD8 T cells provide substantial protection from lethal severe acute respiratory syndrome coronavirus infection. J Virol. 88(19):11034-44.

Channappanavar R, Zhao J, Perlman S. (2014) T cell-mediated immune response to respiratory coronaviruses. Immunol Res. 59(1-3):118-28.

Trujillo JA, Gras S, Twist KA, Croft NP, Channappanavar R, Rossjohn J, Purcell AW, Perlman S. (2014) Structural and functional correlates of enhanced antiviral immunity generated by heteroclitic CD8 T cell epitopes. J Immunol. 192(11):5245-56.

Channappanavar. R, Twardy BS, Suvas S. (2012) Differential effect of blocking PD- 1/PDL-1 interaction in enhancing virus specific CD8 T cell response in young and aged mice. PLoS One. 7(7):e39757.

Channappanavar. R, Singh KP, Singh R and Pandey AB. (2012) Enhanced pro- inflammatory cytokine activity during experimental BTV-1 infection in Indian native sheep. Vet Immunol Immunopathol. 15;145 (1-2):485-92.

Umeshappa CS, Singh KP, Nanjundappa RH, Channappanavar R, Maan S, Maan NS (2012). Bluetongue virus–23 stimulates inducible nitric oxide synthase expression and nitric oxide production in mononuclear cells of blood and/or regional lymphoid organs. Vet Res Commun. 2012 Sep 25.

Twardy.B,S., Channappanavar. R., Suvas. S. (2011) Level of neuropeptide Substance P correlates with the severity of herpetic stromal keratitis. Invest Ophthalmol Vis Sci. 4; 52 (12):8604-13.

Umeshappa. C. S., Singh. K. P., Channappanavar. R., Sharma K., Nanjundappa. R.H., Singh. R., Sharma. A.K., Singh. M (2011). Enhanced clinico-pathology, and viral and immune responses following intradermal inoculation of BTV-23 serotype in Indian native sheep . Vet Immunol Immunopathol. 15;141 (3-4):230-8.

Ingale. S, L., Singh. P, Raina. O.K, Verma. A, K., Channappanavar. R., Mehra. U, R. (2010) Interleukin-2 and interleukin-10 gene expression in calves experimentally infected with Fasciola gigantica. Livestock Science. 131 (1): 141-143.

Channappanavar. R, Twardy B S, Pratima K and Suvas S. (2009) Advancing age leads to predominance of inhibitory receptor expressing CD4 T cells. Mechanism of ageing and development. 130(10): 709-12.

Award(s)

• 2007-Young Scientist Award, Indian Association of Veterinary Pathologists for MVSc thesis work during 24th annual conference at Tirupati Veterinary College, India
• 2010-Graduate Student Research Travel Grant, 97th Annual AAI conference, Baltimore, MD
• 2011-12-Provost Grant for Graduate Research, Oakland University
• 2011-International Students Scholarly Achievement, Oakland University
• 2015-Levitt Centre for Virus Pathogenesis travel award to attend Keystone Meeting on Viral Immunity, Breckenridge, Colorado